Yatan Sizofreni Hastalarinda Çoklu Antipsikotik Kullanimi/Antipsychotic Polypharmacy in Schizophrenic Inpatients

ÖZET. Amaç: Son yillarda yeni antipsikotiklerin bulunmasi ile birlikte, klinisyenlerin antipsikotikleri çoklu olarak kullandigi gözlenmektedir. Bu çalismada Bakirköy Ruh ve Sinir Hastaliklari Egitim ve Arastirma Hastanesi'nde sizofreni tanisi ile yatarak tedavi gören hastalarda antipsikotiklerin bir arada kullanilma sikligini ve bunun sosyodemografik özellikler ve hastalik özellikleri ile iliskisini arastirmak amaçlanmistir. Yöntemler: 2003 yilinda sizofreni tanisi ile yatarak tedavi gören ve es tanisi olmayan 272 hastanin yatis dosyalari ve yatistan sonraki 1 yila kadar olan poliklinik kayitlari geriye dönük olarak incelenmistir. Hastalarin sosyodemografik verileri, hastalik ve yatis bilgileri ve psikofarmakolojik tedavileri degerlendirilmistir. Bulgular: Yatarak tedavi gören sizofreni hastalarinda çoklu antipsikotik kullanimi %48.89 oraninda görülmüstür. Çoklu antipsikotikler içerisinde, %64.66 orani ile en sik birinci kusak-birinci kusak antipsikotikler kullanilmistir (p<0.05). Çoklu antipsikotik kullanan hastalarda bir yil içerisindeki tekrar yatis sayisi daha fazla bulunmustur (p<0.05). Çoklu antipsikotik kullanan hastalarda hastaligin daha erken yas- ta basladigi saptanmistir (p<0.05). Çoklu antipsikotik kullanan hastalarda hastalik süresi, kullanmayanlara göre daha uzun bulunmustur (p<0.05). Yatis süresinin çoklu antipsikotik kullanan hastalarda kullanmayanlara göre daha kisa oldugu saptanmistir (p<0.05). Sonuç: Yatarak tedavi gören sizofreni hastalarinda çoklu antipsikotik kullanimi, çali smamizda diger yayinlarla benzer bir sekilde yüksek (%48.89) saptanmistir. Antipsikotiklerin çoklu kullanimi hastalik baslangiç yasinin küçük olmasi, hastalik süresinin uzun olmasi ve daha kisa yatis süresi ile iliskili bulunmustur. (Nöropsikiyatri Arsivi 2010; 47: 23-8). Anahtar kelimeler: Antipsikotik, sizofreni, çoklu kullanim, yatan hasta. ABSTRACT. Objective: Since new anti-psychotics have been developed in recent years and their use became increasingly common, clinicians prefer treatment with antipsychotic polypharmacy. The aim of this survey is to determine the prevalence of antipsychotic polypharmacy in patients with schizophrenia at the inpatient unit in Bakirköy Mental Health and Neurological Diseases Training and Research Hospital and to investigate the relationship between antipsychotic polypharmacy, and sociodemographic factors and patient characteristics. Methods: We evaluated the medical records of 272 patients who were diagnosed with schizophrenia without comorbid psychiatric disorders at the inpatient clinic, Bakirköy Mental Health and Neurological Diseases Training and Research Hospital, in 2003 and their records of one-year follow-up period after discharge, retrospectively. Data on sociodemographic features and pharmacological treatments collected from the inpatient records were evaluated. Results: The prevalence rate of antipsychotic polypharmacy use in the treatment of patients with schizophrenia was found to be 48.89%. The most frequently prescribed combination was the first generation+ first generation antipsychotics (64.66 %). The number of the patients rehospitalized within one year was higher in those who had been treated with antipsychotic polypharmacy (p<0.05). The patients treated with antipsychotic polypharmacy were with earlier age at onset of the disease compared to patients with monotherapy (p<0.05). The patients treated with antipsychotic polypharmacy had longer duration of illness than the patients with monotherapy (p<0.05). The patients treated with antipsychotic polypharmacy had shorter duration of hospital stay than patients with monotherapy (p<0.05). Conclusion: We found the frequency of antipsychotic polypharmacy in inpatients with schizophrenia to be 48.89 %, which is similar to the literature. The antipsychotic polypharmacy was observed to be associated with earlier age at illness onset, longer duration of illness and shorter duration of hospital stay. (Archives of Neuropsychiatry 2010; 47: 23-8). Key words: Antipsychotics, schizophrenia, polypharmacy, inpatients.

© Galenos Yayinevi 2010. Provided by ProQuest LLC. All Rights Reserved.

The use of this website is subject to the following Terms of Use