Spectrophotometric Estimation of Zolpidem in Tablets

A simple, sensitive, rapid, accurate and precise spectrophotometric method has been developed for the estimation of Zolpidem tartrate in bulk and pharmaceutical dosage forms. Zolpidem tartrate shows maximum absorbance at 238.5 nm with molar absorptivity of 4.4648 10^sup 4^lit/mol/cm. Beer's law was obeyed in the concentration range of 2-16 g/ml. The limit of detection and limit of quantification were found to be 0.038152 g/ml and 0.114577 g/ml, respectively. Results of analysis were validated statistically and by recovery studies. Keywords: Estimation, Tablets, UV spectroscopy, Zolpidem tartrate.

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