Simultaneous UV spectrophotometric method for the determination of diacerein and aceclofenac in tablets

A simple, rapid, accurate and precise UV spectrophotometric method was developed for the simultaneous determination of diacerein (DCN) and aceclofenac (ACF) in tablet dosage forms. The method involved solving simultaneous equations based on measurement of absorbance at two wavelengths, 258 nm and 274 nm, λmax of diacerein and aceclofenac respectively. The linearity for both diacerein and aceclofenac was in the range of 1-10 g/ml and 5-40 g/ml respectively. The % recovery was found to be 99-101 % and 99-100 % for diacerein and aceclofenac respectively indicating proposed method is accurate and precise for simultaneous estimation of DCN and ACF in tablets. Keywords: Aceclofenac, diacerein, dosage form, simultaneous equation, UV spectrophotometry.

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