Differences Between Essential Tremor Developing Parkinson's Disease and Essential Tremor/Parkinson Hastaligi Gelistiren Esansiyel Tremor ile Esansiyel Tremor Arasindaki Farkliliklar

Objective: Essential tremor (ET) is the most prevalent extrapyramidal disorder and some ET patients may later develop Parkinson's disease (PD). However, up to date, precise association was not determined. To understand the relationship between ET and PD, we investigated differences between patients with ET and ET developing PD (ETPD) in terms of demographic and clinical characteristics. Methods: One hundred forty-four patients with ET and 336 PD patients were retrospectively assessed from their clinical charts, and their current age, gender, onset age of ET, family history of ET, asymmetrical or symmetrical tremor and history of REM-Sleep Behavior Disorders (REM-SBD) were recorded. Results: Thirty-three patients who had ET prior to PD were evaluated as ETPD patients based on previous clinical records. The mean duration from ET to PD was 12±11.4 years (range: 1-47). There was no difference in gender between the groups. The mean age, the mean age at ET onset, asymmetrical tremor and REM-SBD history were significantly lower in ET patients compared to ETPD patients. The family history of ET and head tremor was more frequent in ET patients than in ETPD. Conclusions: Our results point out that some patients with ET, having asymmetrical tremor, late onset and REM-SBD history may develop PD. (Archives of Neuropsychiatry 2010; 47: 101-4). Key words: Essential tremor, Parkinson's disease, demographic and clinical characteristics. ÖZET. Amaç: Esansiel tremor (ET) en yaygin ekstrapiramidal hastaliktir ve bazi ET hastalari sonradan Parkinson Hastaligi (PH) gelistirebilirler. Ancak bugüne kadar kesin bir birliktelik tanimlanmamistir. Biz ET ve PH arasindaki iliskiyi anlamak için, ET ile ET sonrasi PH gelistiren hastalar arasindaki farkliliklari demografik ve klinik açidan arastirdik. Yöntemler: Yüz kirk dört ET ve 336 PH hastasi retrospektif olarak klinik kayitlari ndan degerlendirildi ve yas, cinsiyet, ET baslama yasi, ailede ET öyküsü, asimetrik veya simetrik tremor REM-uyku davranis bozuklugu (REM-SBD) öyküsü kaydedildi. Bulgular: Otuz üç PH öncesi ET'si olan hasta önceki klinik kayitlarina dayanarak ETPD hastasi olarak degerlendirildi. ET'den PH'e dönme süresi ortalama 12±11.4 yil idi (1-47). Gruplar arasinda cinsiyet farkliligi yoktu. ET hastalarinda ETPD hastalari ile karsilastirildiginda ortalama yas, ET baslama yasi, asimetrik tremor ve REM-SBD öyküsü anlamli olarak daha azdi. ET hastalarinda ailede ET öyküsü ve bas tremoru ETPD'den daha fazla idi. Sonuç: Bizim sonuçlarimiz asimetrik tremor, geç baslangiçli ET ve REM-SBD öyküsü olan ET hastalarinin sonradan PH gelistirebilecegine dikkati çekmistir. (Nöropsikiyatri Arsivi 2010; 47: 101-4). Anahtar kelimeler: Esansiel tremor, Parkinson Hastaligi, demografik ve klinik özellikler.

© Galenos Yayinevi 2010. Provided by ProQuest LLC. All Rights Reserved.

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