TANNER'S CASSIA (CASSIA AURICULATA L) EXTRACT PREVENTS HEMOGLOBIN GLYCATION AND TAIL TENDON COLLAGEN PROPERTIES IN EXPERIMENTAL DIABETIC RATS

The present study investigated the beneficial effect of Tanner's cassia (Cassia auriculta L) extract which prevents hemoglobin glycation and tail tendon collagen properties in streptozotocin (STZ) -induced diabetic rats. The effects of an aqueous extract of Tanner's cassia and glybenclamide on plasma glucose, insulin, glycosylated hemoglobin and the collagen properties such as total collagen, extent of glycation, advanced glycation end product (AGE) linked fluorescence, lipid peroxidation (hydroperoxides), neutral salt, acid and pepsin soluble collagen were examined in tail tendon of control and experimental groups. Oral administration of Tanner's cassia (0.45 mg/kg/bw) aqueous extract and glibenglamide to diabetic rats for 45 days significantly reduced blood glucose, glycosylated hemoglobin with increased level of insulin and prevented the abnormalities of tail tendon collagen properties. The results showed that Tanner's cassia extract has antihyperglycaemic properties and prevents the abnormalities of collagen properties in tail tendon of STZ-induced diabetic rats. Tanner's cassia extract administration is more effective than glibenclamide. Key words: Tanner's cassia, Hemoglobin glycation, Tail tendon collagen, Diabetes mellitus.

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