Preparation and Evaluation of Sustained Release Matrix Tablet of Diclofenac Sodium using Natural Polymer

Sustained release tablets of Diclofenac Sodium were fabricated using Cashew nut tree gum, HPMC and Carbopol . The tablets were evaluated for preformulation studies like angle of repose, bluk density, compressibility index and physical characteristics like hardness, weight variation, fraibilty and drug content. In-vitro release of drug was performed in PBS pH 7.2 for twelve hours. All the physical characters of the fabricated tablet were within acceptablelimits. The tablet with HPMC(Batch B-I) and Carbopol(Batch C-I) exhibited greater drug content than those with cashew nut tree gum and other batches of HPMC and carbopol. A better sustained drug release (50.65%) was obtained with the matrix tablet (Batch C-III) made-up of the carbopol than with the cashew nut tree gum and HPMC. It is cleared through the dissolution profile of Diclofenac sodium from matrix tablets prepared using different polymers were indicated an increase in the polymer ratio retarded the drug release to a greater extent. Key words: Diclofenac sodium, Cashew nut tree gum, HPMC, Carbopol, Sustained release matrix tablets.

© Journal of Pharmaceutical Sciences and Research Jun 2010. Provided by ProQuest LLC. All Rights Reserved.

The use of this website is subject to the following Terms of Use