The Influence of Vascular Endothelial Growth Factor (VEGF) Polymorphism on the Progression of Chronic Glomerulonephritides

(vascular endothelial growth factor / IgA nephropathy / focal segmental glomerulosclerosis / membranous glomerulonephritis / gene promoter polymorphism). Abstract. Vascular endothelial growth factor is an important mediator in maintaining normal kidney functions. In addition, several lines of evidence show that up-regulation of this mediator in glomeruli may be associated with or may directly cause renal dysfunction. We tried to assess the influence of the -2578 C/A and -1154 G/A polymorphisms in the regulatory region of the vascular endothelial growth factor gene upon progression of three primary chronic glomerulonephritides (minimal change disease/focal and segmentai glomerulosclerosis, membranous nephropathy, immunoglobulin A nephropathy). We studied a cohort of 213 patients compared to 311 unrelated healthy controls. Analysis of the C/A polymorphism of vascular endothelial growth factor revealed an increased prevalence of CC genotype in the minimal change disease/focal and segmental glomerulosclerosis group in comparison with the other groups. A balanced distribution of G and A alleles among the respective types of chronic glomerulonephritides was shown in the analysis of -1154 G/A polymorphism. Finally, we have not proved any significant influence of the polymorphisms at positions -2578 C/A and -1154 G/A of the vascular endothelial growth factor gene promoter on the progression of chronic glomerulonephritides even though our study suggests a negative effect of CC genotype of -2578 C/A polymorphism on the clinical course of minimal change disease/focal segmental glomerulosclerosis. Abbreviations: ADPKD - autosomal-dominant polycystic kidney disease, ESRF - end-stage renal failure, FSGS - focal and segmental glomerulosclerosis, GFR - glomerular filtration rate, GN - glomerulonephritis, IgAN - immunoglobulin A nephropathy, MCD -minimal change disease, MDRD formula - modification of diet in renal disease formula, MGN - membranous nephropathy, PCR - polymerase chain reaction, S-albumin/creatinine - serum albumin/creatinine, UTR - untranslated region, VEGF - vascular endothelial growth factor, VEGFR1/2 - vascular endothelial growth factor receptor 1/2.

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