Evaluation of the Leaves of Ipomoea aquatica for its Hypoglycemic and Antioxidant Activity

The present study was accomplished to explore the hypoglycemic and antioxidant activity of methanolic extracts of the leaves of I .aquatica. The animals used to test the antidiabetic activity were Swiss albino mice of 7-8 weeks, average weight 20-30 gm of both male and female sexes. Twenty four mice were randomly grouped into four where there were two drug groups, one control and one standard control group. Metformin was used as standard in the testing of hypoglycemic activity. Different doses as 200 mg/kg and 400 mg/kg body weight of extract were used during the course of study. Both of the doses showed potent hypoglycemic activity in comparison with the control (P<0.001). But more activity was observed incase of 400 mg/kg body weight dose. Incase of antioxidant effect, the extract showed potent free radical scavenging activity with IC50 value of 4.4 g/ ml. Ascorbic acid was used as standard with IC^sub 50^ value of 15.83 g/ ml. Key words: Diabetes mellitus (DM), Ipomoea aquatica, 1, 1-diphenyl-2 picrylhydrazyl (DPPH), streptozocin, hypoglycemia.

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